Classification of cancer level based on genomic coordinates of outermost nucleotides of cell-free DNA
US10297342B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | May 5, 2017 |
| Grant date | May 21, 2019 |
| Priority date | — |
| Expiry date | May 5, 2037 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG16H50/30
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
A classification of a level of cancer in an organism is determined by analyzing a biological sample of the organism. The biological sample comprises clinically-relevant DNA and other DNA. At least some of the DNA is cell-free in the biological sample. An amount of a first set of DNA fragments from the biological sample corresponding to each of a plurality of sizes is measured. A first value of a first parameter is calculated based on the amounts of DNA fragments at the plurality of sizes. The first value is compared to a reference value. A classification of a level of cancer in the organism is determined based on the comparison.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.