Compositions and methods for nanoparticle lyophile forms
US10300018B2 · kind B2 · utility
2Cited by
4References
29Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jul 22, 2016 |
| Grant date | May 28, 2019 |
| Priority date | — |
| Expiry date | Jul 22, 2036 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2320/32
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
This invention provides compositions for making a solid lyophile of one or more nucleic acid active agents, which can be reconstituted as a drug product. The composition can include an aqueous suspension of lipid nanoparticles in a pharmaceutically acceptable solution, wherein the lipid nanoparticles encapsulate one or more nucleic acid active agents, a dextrin compound, and a saccharide compound. The nucleic acid active agents can be RNAi molecules capable of mediating RNA interference, as well as other RNAs and oligonucleotides.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.