Compositions for enhancing transport of molecules into cells
US10300149B2 · kind B2 · utility
1Cited by
47References
18Claims
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Key dates
| Filing date | Jan 10, 2017 |
| Grant date | May 28, 2019 |
| Priority date | — |
| Expiry date | Jan 10, 2037 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2320/32
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Compositions and methods for enhancing delivery of molecules, e.g. biological agents, into cells are described. The composition is a conjugate of the biological agent, preferably a nucleic acid analog having a substantially uncharged backbone, covalently linked to a peptide transporter moiety as described. Conjugation of the peptide transporter to a substantially uncharged nucleic acid analog, such as a morpholino oligomer, is also shown to enhance binding of the oligomer to its target sequence and enhance antisense activity.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.