Small molecule inhibitors of botulinum neurotoxins

US10301265B2 · kind B2 · utility

Inventors

• Virginia I. Roxas-Duncan · Fort Detrick, US
• Leonard A. Smith · Clarksburg, US
• Nizamettin Gul · Fort Detrick, US
• John H. Cardellina, II · Fort Detrick, US
• Rebecca C. Vieira · Fort Detrick, US
• Susan M. Ensel · Fort Detrick, US
• David C. Yang · Houghton, US
• Istvan Enyedy · Hamden, US
• Sivanesan Dakshanamurthy · Herndon, US
• Salimuddin Shah · Washington, US

Key dates

• Filing date: May 28, 2009
• Grant date: May 28, 2019
• Expiry date: May 28, 2029

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D401/12
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The invention provides potent quinolinol-based BoNT/A small-molecule inhibitors of botulinum neurotoxins, in particular of Clostridium botulinum serotype A neurotoxins. The invention also provides methods of using these small-molecule inhibitors to inhibit infections by Clostridium botulinum, as well as, methods of preventing infections by Clostridium botulinum through materials that may be ingested.