Compounds and methods for kinase modulation, and indications therefor

US10301280B2 · kind B2 · utility

Assignee

• Plexxikon Inc. · US

Inventors

• Guoxian Wu · Palo Alto, US
• Katrina Chan · Fremont, US
• Todd Ewing · San Diego, US
• Prabha N. Ibrahim · Mountain View, US
• Jack Lin · Hercules, US
• Marika Nespi · Berkeley, US
• Wayne Spevak · Berkeley, US
• Ying Zhang · Beijing, CN

Key dates

• Filing date: Jun 12, 2017
• Grant date: May 28, 2019
• Expiry date: Jun 12, 2037

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07F9/65616
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compounds active on c-kit protein kinases or mutant c-kit protein kinases having any mutations are described, as well as methods of making and using such compounds to treat diseases and conditions associated with aberrant activity of the c-kit protein kinases and/or mutant c-kit protein kinases.