Compositions and methods of chimeric autoantibody receptor T cells
US10301370B2 · kind B2 · utility
4Cited by
3References
16Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | May 1, 2015 |
| Grant date | May 28, 2019 |
| Priority date | — |
| Expiry date | May 1, 2035 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2319/03
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention includes compositions comprising at least one chimeric autoantibody receptor (CAAR) specific for an autoantibody, vectors comprising the same, compositions comprising CAAR vectors packaged in viral particles, and recombinant T cells comprising the CAAR. The invention also includes methods of making a genetically modified T cell expressing a CAAR (CAART) wherein the expressed CAAR comprises a desmoglein extracellular domain.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.