Methods, compositions, and systems for activation and expansion of cells

US10301590B2 · kind B2 · utility

Assignee

• The Trustees of Columbia University in the City of New York · US

Inventors

• Lance Kam · New York, US
• Helen H. Lu · New York, US
• Sarah E. De Leo · Baton Rouge, US
• Keenan BASHOUR · Seattle, US
• Danielle Bogdanowicz · Somers, US
• Philip Chuang · Pingtung City, TW

Key dates

• Filing date: Apr 10, 2015
• Grant date: May 28, 2019
• Expiry date: Jul 21, 2035

Classification

• Technology area (CPC D): Textiles; Paper
• CPC primary: D06M2101/32
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The disclosure provides for compositions, systems, and methods of cell expansion, stimulation and/or differentiation. The disclosure further provides for a mesh substrate and associated methods capable of stimulating cell expansion, for example, T cell or stem cell expansion. In another aspect, the disclosure provides for an electrospun mesh substrate and methods of using thereof comprising a silicone rubber composition, for example, polydimethylsiloxane, PLC, or combinations thereof.