Patent · US Active

Normalization of nucleic acid libraries

US10301677B2 · kind B2 · utility

33Cited by

117References

20Claims

0Family size

Assignee

CELLULAR RESEARCH, INC. · US

Inventors

Eleen Shum · San Jose, US
Glenn K. Fu · Dublin, US
Craig Betts · Menlo Park, US

Key dates

Filing date	May 23, 2017
Grant date	May 28, 2019
Priority date	—
Expiry date	May 23, 2037

Classification

Technology area (CPC G)Physics
CPC primaryG16B25/10
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

This disclosure provides methods and compositions for removing one or more high abundance species from a plurality of nucleic acid molecules. In some embodiments, the methods and compositions can be used for normalizing nucleic acid libraries. In some embodiments, molecular labels are used in conjunction with the methods and compositions disclosed herein to improve sequencing efficiency.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.