Donepezil transdermal delivery system
US10307379B2 · kind B2 · utility
6Cited by
54References
18Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Apr 19, 2018 |
| Grant date | Jun 4, 2019 |
| Priority date | — |
| Expiry date | Apr 19, 2038 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K31/045
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A transdermal delivery system for systemic delivery of donepezil is described, where the system comprises an adhesive matrix drug reservoir layer comprised of a copolymer of acrylic acid/vinyl acetate, triethyl citrate, and donepezil base generated in situ by reaction of donepezil HCl and an alkaline salt. The system is provided for treatment of Alzheimer's disease, and achieves transdermal delivery of the therapeutic agent at steady state that is bioequivalent to administration of the therapeutic agent orally.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.