Methods for inducing an immune response against human immunodeficiency virus infection in subjects undergoing antiretroviral treatment

US10307477B2 · kind B2 · utility

Assignees

• Janssen Vaccines & Prevention B.V.
• The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. · US
• Beth Israel Deaconess Medical Center, Inc. · US
• The United States of America as represented by the Secretary of the Army · US

Inventors

• Frank TOMAKA · Titusville, US
• Maria Grazia Pau · Leiden, NL
• Johanna SCHUITEMAKER · Amstelveen, NL
• Dan H. Barouch · Newton, US
• Jintanat Ananworanich · Rockville, US
• Merlin Robb · Silver Spring, US
• Nelson Michael · Fort Detrick, US
• Jerome Kim · Fort Detrick, US

Key dates

• Filing date: Sep 1, 2017
• Grant date: Jun 4, 2019
• Expiry date: Sep 1, 2037

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2740/16271
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Methods for inducing an immune response against Human Immunodeficiency Virus (HIV) in HIV-infected subjects undergoing antiretroviral therapy (ART) are described. The methods include administering an adenovirus vector primer vaccine and a modified vaccinia virus (MVA) vector booster vaccine encoding mosaic HIV antigens.