Organoselenium compounds, method for producing same, and pharmaceutical uses thereof in particular as antitumor agents

US10308602B2 · kind B2 · utility

Assignee

• TETRAHEDRON · FR

Inventors

• Jean-Claude Yadan · Montreuil, FR
• Irene Erdelmeier · Paris, FR
• Marc Moutet · Bagneux, FR
• Rémi Lebel · Drancy, FR

Key dates

• Filing date: Apr 7, 2015
• Grant date: Jun 4, 2019
• Expiry date: Apr 7, 2035

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C2603/18
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to a selenium compound. Said selenium compound has formula (I), where R1=alkyl; R2=H, R4C(=0), R4OC(=0), a-aminoacyl, CH3SeCH2CH2CH(NH2)C(=0), CH3SeCH2CH2CH(OH)C(=0); X=OH, OR3, NH2, NR4R5, α-amino acid, CH3SeCH2CH2CH(COOH)NH—, CH3SeCH2CH2CH(COOH)0-; R3=alkyl; R4=alkyl, aryl; R5=H, alkyl, aryl; R4 and R5 which can together form a 5- or 6-membered cycloalkyl radical which can comprise a heteroatom; provided that when X=NH-terbutyl, R2≠C(=0)CH3. Said compound can be used as a pharmaceutical substance, in particular as an antitumour substance.