Small molecule inhibitors of Ku70/80 and uses thereof
US10308656B2 · kind B2 · utility
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7References
9Claims
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Assignee
Inventors
Key dates
| Filing date | Aug 16, 2016 |
| Grant date | Jun 4, 2019 |
| Priority date | — |
| Expiry date | Aug 16, 2036 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D413/12
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Provided herein are methods for identifying and treating subjects having conditions involving aberrant Ku70/80 activity. In particular, the invention relates to small-molecules which function as inhibitors of Ku70/80 protein and the non-homologous end-joining (NHEJ) pathway, and their use as therapeutics for the treatment of cancer and other diseases.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.