Coupling method for peptide synthesis at elevated temperatures
US10308677B2 · kind B2 · utility
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5References
18Claims
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Key dates
| Filing date | Dec 15, 2015 |
| Grant date | Jun 4, 2019 |
| Priority date | — |
| Expiry date | Mar 26, 2036 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K14/57581
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
An improved method for coupling carboxylic acids and amines is disclosed that includes the steps of combining a hyper-acid sensitive linker connecting an amine and a resin, a carboxylic acid, a carbodiimide, an activator additive, and a base, and carrying out the activation and coupling at a temperature greater than 30° C.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.