Patent · US Active

Mutated immunoglobulin-binding polypeptides

US10308690B2 · kind B2 · utility

0Cited by

0References

27Claims

0Family size

Assignee

GE Healthcare BioProcess R&D AB · SE

Inventors

Gustav Rodrigo · Uppsala, SE
Mats Ander · Uppsala, SE
Goran Bauren · Uppsala, SE
Tomas Bjorkman · Uppsala, SE

Key dates

Filing date	Dec 7, 2015
Grant date	Jun 4, 2019
Priority date	—
Expiry date	Jun 3, 2037

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07K16/00
WIPO fieldChemical engineering
WIPO sectorChemistry

Abstract

The invention discloses a polypeptide with improved alkaline stability, which polypeptide comprises a mutant of a B or C domain of Staphylococcus Protein A (SpA), as specified by SEQ ID NO 1 or SEQ ID NO 2, or of Protein Z, as specified by SEQ ID NO 3, comprising at least the mutation wherein the glutamine residue at position 9 has been mutated to a tryptophan, leucine, glutamic acid, valine or lysine. The invention also discloses multimers of the polypeptide, as well as separation matrices comprising the multimers or polypeptides.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.