Methods for controlling fucosylation levels in proteins

US10308970B2 · kind B2 · utility

Assignee

• Biocon Ltd. · IN

Inventors

• Pradip Nair · Savanuru, IN
• Ramakrishnan Melarkode · Savanuru, IN
• Rasika Venkataraman · Bengaluru, IN
• Laxmi Adhikary · Savanuru, IN
• Ankur Bhatnagar · Bengaluru, IN
• Sunaina Prabhu · Sirsi, IN
• Kriti Shukla · Ahmedabad, IN
• Dinesh Baskar · Bengaluru, IN
• Saravanan Desan · Bengaluru, IN
• Harish Venkatraman Pai · Bengaluru, IN
• Jose Enrique Montero Casimiro · Havana, CU

Key dates

• Filing date: Nov 21, 2017
• Grant date: Jun 4, 2019
• Expiry date: Nov 21, 2037

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02A50/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to a method or process for controlling, inhibiting or reducing protein fucosylation in a eukaryote and/or eukaryotic protein expression system. Said method comprises carrying out the protein expression and/or post-translational modification in the presence of an elevated total concentration of manganese or manganese ions.