Patent · US Active

Microorganism for expressing a human membrane protein

US10308971B2 · kind B2 · utility

0Cited by

1References

11Claims

0Family size

Assignee

Novozymes A/S · DK

Inventors

Michael Schilling · Clinton, US
Christine Lang · Berlin, DE
Andreas Raab · Neuler, DE

Key dates

Filing date	Feb 7, 2018
Grant date	Jun 4, 2019
Priority date	—
Expiry date	Feb 7, 2038

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12P21/02
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

The invention relates to an isolated, genetically modified, living non-mammal organism, having increased HMG-CoA-reductase activity compared to the wild type, and having reduced C24-methyltransferase and/or delta22-desaturase activity compared to the wild type. The invention is characterized in that the organism has increased dehydrocholesterol-delta70-reductase activity compared to the wild type. The invention further relates to different uses of such an organism, to a test kit comprising such an organism, and to a membrane extract of such an organism.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.