Device and method for processing a biological sample and analysis system for analyzing a biological specimen

US10308977B2 · kind B2 · utility

Assignee

• Robert Bosch GmbH · DE

Inventors

• Thomas Brettschneider · Leonberg, DE
• Jochen Hoffmann · Glückstadt, DE
• Karin Lemuth · Stuttgart, DE

Key dates

• Filing date: Apr 29, 2015
• Grant date: Jun 4, 2019
• Expiry date: May 13, 2035

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2001/4088
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

A device for processing a biological sample includes a first substrate having a first cavity, a second substrate having a second cavity, a filter element having a plurality of perforations, and an electrically conductive structure. The first cavity forms a first chamber segment of a chamber for accommodating the biological sample. The second cavity forms a second chamber segment of the chamber for accommodating the biological sample. The filter element is formed between the first cavity and the second cavity in order to hold back a plurality of organic cells of the biological sample on the plurality of perforations when the biological sample moves between the first cavity and the second cavity through the filter element. The electrically conductive structure is arranged on the filter element and is configured to cause lysis of the organic cells and/or to duplicate and/or detect defined segments of exposed DNA.