Method for detecting chromosome structure and gene expression simultaneously in single cells
US10308983B2 · kind B2 · utility
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2References
23Claims
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Key dates
| Filing date | Feb 6, 2012 |
| Grant date | Jun 4, 2019 |
| Priority date | — |
| Expiry date | Nov 17, 2032 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Q2600/158
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present invention relates to systems and methods for measuring chromosome structure and gene expression. In one embodiment, the present invention includes an assay for determining the spatial organization of gene expression in the nucleus. The present invention also includes a method based on fluorescence in situ hybridization (FISH) that simultaneously yields information on the physical position and expression of individual genes. By lighting up a large number of targets on a particular chromosome using a bar-coding scheme, the large scale structure of an entire chromosome can be determined.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.