Preparation containing chlorogenic acid crystal form and use thereof

US10314806B2 · kind B2 · utility

Assignee

• SICHUAN JIUZHANG BIOLOGICAL SCIENCE AND TECHNOLOGY CO., LTD · CN

Inventors

• Jie Zhang · Beijing, CN
• Lina Zhu · San Jose, US
• Wang Huang · Sichuan, CN
• Liang Zhang · Sichuan, CN

Key dates

• Filing date: Nov 18, 2015
• Grant date: Jun 11, 2019
• Expiry date: Nov 18, 2035

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P39/06
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A preparation containing a chlorogenic acid crystal form. The crystal form is an orthorhombic crystal system, a space group is P212121, cell parameters are as follows: a=7.7291(2)Å, b=10.9808(2)Å, c=36.5334(7)Å, α=β=γ=90.00°, Z=8, and a cell volume is 3100.65(11)Å3. The content of the chlorogenic acid crystal form in the preparation is 10-5000 mg/g. The preparation is advantageous to bioavailability, and can be used for preparing medicines for treating tumor, psoriasis and other immune system diseases, resisting oxidation, protecting liver and gallbladder, treating cardiovascular diseases, and resisting viruses.