Patent · US Active

Trimaleimide linkers and uses thereof

US10314922B2 · kind B2 · utility

0Cited by

0References

9Claims

0Family size

Assignee

NewBio Therapeutics, Inc. · CN

Inventors

Nianhe Han · Newbury Park, US
Deqiang An · Shanghai, CN
Di Zeng · Shanghai, CN
Baoxiang Wang · Shanghai, CN
Hang Yang · Shanghai, CN
Li Jian · Shanghai, CN
Chun-Ying Yang · Taipei, TW

Key dates

Filing date	May 17, 2016
Grant date	Jun 11, 2019
Priority date	—
Expiry date	May 17, 2036

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07K2317/24
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

A type of trimaleimide linkers and uses thereof are disclosed. The trimaleimide linkers can be applied for preparation of antibody-drug conjugate as shown by formula I: L-(T-A-D)n I wherein, L is an antibody, antibody fragment or protein; T is a trimaleimide linker; A is a cleavable linker group or a noncleavable linker; D is a drug; n is an integer ranging from 1 to 8.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.