Bicyclic-fused heteroaryl or aryl compounds as IRAK4 modulators

US10316018B2 · kind B2 · utility

Assignee

• PFIZER INC. · US

Inventors

• Katherine Lin Lee · Newton, US
• Christophe Philippe Allais · Ledyard, US
• Christoph Martin Dehnhardt · New York, US
• Lori Krim Gavrin · Philadelphia, US
• Seungil Han · Mystic, US
• David Hepworth · Concord, US
• Arthur Lee · San Jose, US
• Frank Eldridge Lovering · Acton, US
• John Paul Mathias · Sandwich, GB
• Dafydd Rhys Owen · Concord, US
• Nikolaos Papaioannou · Newton, US
• Eddine Saiah · Brookline, US
• Joseph Walter Strohbach · Mendon, US
• John David Trzupek · Medford, US
• Stephen Wayne Wright · Old Lyme, US
• Christoph Wolfgang Zapf · San Francisco, US

Key dates

• Filing date: Nov 30, 2018
• Grant date: Jun 11, 2019
• Expiry date: Nov 30, 2038

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D491/18
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compounds, tautomers and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula Ia, as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.