Fidaxomicin purification method
US10316052B2 · kind B2 · utility
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15Claims
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Key dates
| Filing date | Jul 7, 2015 |
| Grant date | Jun 11, 2019 |
| Priority date | — |
| Expiry date | Oct 21, 2035 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12P19/62
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A fidaxomicin purification method, comprising: fermenting Actinoplanes sp. HS-16-20 to generate fermented liquid; conducting solid/liquid separation on the fermented liquid, soaking mycelium in an organic solvent, and filtering to obtain a solution containing fidaxomicin; treating the solution with nanofiltration concentrate, and separating to obtain fidaxomicin crude product; conducting preparative column chromatography on the fidaxomicin crude product, eluting with an acid aqueous solution containing an organic solvent, and separating to obtain the refined fidaxomicin product.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.