Preparation and use of crystalline beta-D-nicotinamide riboside

US10316054B2 · kind B2 · utility

Assignee

• GlaxoSmithKline Intellectual Property (No. 4) Limited · GB

Inventors

• Bruce Szczepankiewicz · Gages Lake, US
• Karsten Koppetsch · Woburn, US
• Robert B. Perni · Marlborough, US

Key dates

• Filing date: Jun 2, 2015
• Grant date: Jun 11, 2019
• Expiry date: Jun 2, 2035

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07B2200/13
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Provided herein are crystalline beta-D-nicotinamide riboside chloride compositions and methods of preparation and use thereof. Also provided are related pharmaceutical compositions and methods of use thereof. The crystalline beta-D-nicotinamide riboside chloride compositions may be used to treat a disease or disorder that would benefit from increased NAD levels including a mitochondrial disease or disorder, insulin resistance, a metabolic syndrome, diabetes, obesity, or for increasing insulin sensitivity in a subject.