Lactone hydrolase and method of degrading alpha-zearalenol using the same

US10316303B2 · kind B2 · utility

Assignee

• TIANJIN INSTITUTE OF INDUSTRIAL BIOTECHNOLOGY, CHINESE ACADEMY OF SCIENCES · CN

Inventors

• Rey-Ting Guo · Tianjin, CN
• Yingying Zheng · Tianjin, CN
• Zhongxia Xu · Tianjin, CN
• Chun-Chi Chen · New Taipei, TW
• Wei Peng · Port Aransas, US
• Weidong Liu · Qinhuangdao City, CN
• Je-Ruei Liu · Tianjin, CN
• Yanhe Ma · Tianjin, CN

Key dates

• Filing date: Dec 1, 2016
• Grant date: Jun 11, 2019
• Expiry date: Dec 20, 2036

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12Y301/01
• WIPO field: Food chemistry
• WIPO sector: Chemistry

Abstract

A lactone hydrolase having improved activity towards α-zearalenol is disclosed. The lactone hydrolase has a modified amino acid sequence of SEQ ID NO: 5, wherein the modification is a substitution of valine at position 167 with histidine. A method of degrading α-zearalenol using such lactone hydrolase is also disclosed.