Compositions for targeted delivery of siRNA

US10316316B2 · kind B2 · utility

Assignee

• Arrowhead Pharmaceuticals, Inc. · US

Inventors

• David L. Lewis · Madison, US
• David B. Rozema · Madison, US
• Darren H. Wakefield · Fitchburg, US
• Torsten Hoffman · Halle (Saale), DE
• Erik Kitas · Versoix, CH
• Peter Mohr · Basel, CH
• Philipp Hadwiger · Kulmbach, DE
• Wilma Thuer · Kulmbach, DE
• Linda Valis · Bamberg, DE

Key dates

• Filing date: Apr 19, 2016
• Grant date: Jun 11, 2019
• Expiry date: Apr 19, 2036

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2320/32
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention is directed compositions for targeted delivery of RNA interference (RNAi) polynucleotides to hepatocytes in vivo. Targeted RNAi polynucleotides are administered together with co-targeted delivery polymers. Delivery polymers provide membrane penetration function for movement of the RNAi polynucleotides from outside the cell to inside the cell. Reversible modification provides physiological responsiveness to the delivery polymers.