Patent · US Active

Enzymatic process for the preparation of (1S,2R)-2-(difluoromethyl)-1-(propoxycarbonyl)cyclopropanecarboxylic acid

US10316338B1 · kind B1 · utility

2Cited by

3References

13Claims

0Family size

Assignee

Abb Vie Inc. · US

Inventors

Michael J. Abrahamson · Chicago, US
Angelica B. Kielbus · Evanston, US
William T. Riordan · Libertyville, US
David R. Hill · Gurnee, US
Sanjay R. Chemburkar · Gurnee, US
Rajarathnam E. Reddy · Gurnee, US
Timothy B. Towne · Lindenhurst, US
Jianzhang Mei · Lake Forest, US
Gareth Brown · Antrim, GB
Stefan Mix · Craigavon, GB

Key dates

Filing date	Jan 29, 2016
Grant date	Jun 11, 2019
Priority date	—
Expiry date	Dec 28, 2036

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12Y301/01003
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

Disclosed are methods of synthesizing enantioenriched difluoroalkylcyclopropyl amino esters and their salts, such as the dicyclohexylamine salt of (1S,2R)-2-(difluoromethyl)-1-(propoxycarbonyl)cyclopropane carboxylic acid. These compounds are useful intermediates in the synthesis of viral protease inhibitors.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.