System for detecting rare cells

US10317406B2 · kind B2 · utility

Assignee

• THE REGENTS OF THE UNIVERSITY OF MICHIGAN · US

Inventors

• Hyeun Joong Yoon · Brookings, US
• Apoorv Shanker · Ann Arbor, US
• Jinsang Kim · Ann Arbor, US
• Sunitha Nagrath · Ann Arbor, US
• Vasudha Murlidhar · Ann Arbor, US

Key dates

• Filing date: Apr 6, 2016
• Grant date: Jun 11, 2019
• Expiry date: Feb 27, 2037

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2539/10
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

A system for detecting rare cells in a fluid is disclosed. The system includes a substrate and a mixture disposed on the substrate and including a carrier and a thermo-responsive polymer for capture and release of the rare cells. Also disclosed is a method for detecting rare cells in a fluid using a system including a substrate and a mixture that is disposed on the substrate. The mixture includes a carrier and a thermo-responsive polymer. The method includes providing the system and introducing a sample of fluid containing the rare cells into the system such that the sample interacts with the carrier for capturing the rare cells.