Systems and methods for targeted drug delivery

US10322178B2 · kind B2 · utility

Assignees

• The Trustees of Columbia University in the City of New York · US
• The University of North Carolina at Chapel Hill · US

Inventors

• Chen Chen · Beijing, CN
• Elisa E. Konofagou · New York, US
• Paul Dayton · Davis, US

Key dates

• Filing date: Aug 11, 2014
• Grant date: Jun 18, 2019
• Expiry date: Aug 11, 2034

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61N2007/0039
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Techniques for opening a target tissue using nanodroplets are provided. An exemplary method can include targeting a region of tissue for opening, delivering a plurality of nanodroplets to the region, and applying an ultrasound beam at the region such that the nanodroplets cavitate, or convert to microbubbles that cavitate, thereby causing the target tissue to open.