Reduced toxicity molecular conjugates of anti-fungal agents
US10322187B2 · kind B2 · utility
0Cited by
4References
11Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Aug 10, 2016 |
| Grant date | Jun 18, 2019 |
| Priority date | — |
| Expiry date | Dec 16, 2036 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K47/554
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Compositions, compounds and methods are described for addressing both toxicity of membrane disruptive anti-microbial agents as well as poor transport of such agents across the blood-brain-barrier (BBB) via the use of molecular appendages including one or more facial amphiphiles. These molecules have in vitro anti-fungal activity that is very similar to that of the native drug but with hemolytic activity and toxicity towards mammalian cells that is greatly reduced.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.