Co-crystal of a CDK inhibitor and an MEK inhibitor and process of preparation thereof

US10323035B2 · kind B2 · utility

Assignee

• CRYSTAL PHARMATECH CO., LTD. · CN

Inventors

• Minhua Chen · 安丰镇, CN
• Yanfeng Zhang · Suzhou, CN
• Qiyue LIU · 安丰镇, CN
• Nan Xia · Shaoxing, CN
• Chaohui Yang · Suzhou, CN
• Xiaoyu Zhang · Suzhou, CN

Key dates

• Filing date: Apr 1, 2016
• Grant date: Jun 18, 2019
• Expiry date: Apr 1, 2036

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07B2200/13
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present disclosure relates to novel co-crystals of a CDK inhibitor and an MEK inhibitor and the preparation methods thereof. Specifically, the present disclosure provides hydrates or anhydrates which are named as Form I, Form II and Form III. The novel co-crystals provided in the present disclosure have good stability, low hygroscopicity and high solubility, and have an important value for further optimization and development of the drug.