Process for the preparation of 5-fluorotryptophol

US10323040B2 · kind B2 · utility

Assignee

• Gruenenthal GmbH · DE

Inventors

• Stefan Pruehs · Neuss, DE
• Olaf Schaefer · Biberach an der Riß, DE

Key dates

• Filing date: Aug 26, 2016
• Grant date: Jun 18, 2019
• Expiry date: Oct 10, 2036

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D209/30
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention relates to a process for the preparation of 5-fluorotryptophol as well as a process for the preparation of (1r,4r)-6′-fluoro-N,N-dimethyl-4-phenyl-4′,9′-dihydro-3′H-spiro[cyclohexane-1,1′-pyrano-[3,4b]-indol]-4-amine using the 5-fluorotryptophol obtained by said first process. The process according to the invention provides 5-fluorotryptophol in improved yield and purity without the need for chromatographic purification of the product.