Three-dimensional human stem cell-derived cortical spheroid model
US10323229B1 · kind B1 · utility
Assignee
Inventor
Key dates
| Filing date | Nov 14, 2016 |
| Grant date | Jun 18, 2019 |
| Priority date | — |
| Expiry date | Nov 14, 2036 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2510/00
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The present invention provides a new therapeutic method for modeling neuronal responses. Human induced pluripotent stem cells (hiPSCs) emerge recently as alternative sources of primary brain cells to establish Alzheimer's disease (AD) models in vitro. While previous investigations demonstrate the potential of hiPSCs in modeling AD, the 2-D cultures used in these studies cannot fully recapitulate AD-associated neuropathology. 3-D cortical spheroids (forebrain-like structure) were derived from human induced pluripotent stem cells in a bioreactor culture, which can be used to recapitulate AD-associated neuropathology, to screen the therapeutic drugs and to predict neurotoxicity.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.