Methods and systems for three-dimensional real-time intraoperative surgical margin evaluation of tumor tissues

US10325366B2 · kind B2 · utility

Assignee

• VANDERBILT UNIVERSITY · US

Inventors

• Anita Mahadevan-Jansen · Nashville, US
• The Quyen Nguyen · Evanston, US
• Xiaohong Bi · Nashville, US
• Zain Gowani · Nashville, US
• Ginger Holt · Nashville, US
• Isaac J. Pence · Crestwood, US
• John Nguyen · San Jose, US

Key dates

• Filing date: Oct 12, 2017
• Grant date: Jun 18, 2019
• Expiry date: Oct 12, 2037

Classification

• Technology area (CPC G): Physics
• CPC primary: G06T2207/30096
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

A method of evaluating a surgical margin of tumor tissues of a living subject includes acquiring images of a specimen of the tumor tissues; calculating a three-dimensional (3D) morphological surface of the specimen from the acquired images and displaying the 3D morphological surface; obtaining, from the 3D morphological surface, a plurality of specimen locations to cover a surface of the specimen; acquiring optical data at each specimen location; evaluating a margin status of the specimen at each specimen location to either positive or negative based on the acquired optical data; and displaying the margin status of the specimen on the 3D morphological surface of the specimen with morphological orientations.