Patent · US Active

Pharmaceutical oral dose formulation and composition of matter

US10328067B2 · kind B2 · utility

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4Claims
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Inventor

Key dates

Filing dateAug 21, 2017
Grant dateJun 25, 2019
Priority date—
Expiry dateOct 11, 2037

Classification

  • Technology area (CPC B)Performing Operations; Transporting
  • CPC primaryB01D11/0203
  • WIPO fieldPharmaceuticals
  • WIPO sectorChemistry

Abstract

An apparatus and method for formulating low solubility, low permeability and/or p-glycoprotein efflux transporter substrate drugs or herbal extracts for increased intestinal absorption. The method utilizes a supercritical fluid, such as carbon dioxide to complex a low solubility, low permeability and/or p-glycoprotein efflux transporter substrate drug or herbal extract, the p-glycoprotein inhibitors quercitin and piperine, with a carbohydrate. The result is a micro-emulsion of the drug or herbal extract which has both higher solubility and permeability than if dosed alone; as well as resistance to p-glycoprotein mediated efflux, once absorbed into the intestinal lumen.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.