Compositions and methods of enhancing immune responses to Eimeria or limiting Eimeria infection

US10328137B2 · kind B2 · utility

Assignees

• THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS · US
• THE TEXAS A&M UNIVERSITY SYSTEM · US

Inventors

• John R. Barta · Guelph, CA
• Luc Berghman · College Station, US
• Srichaitanya Shivaramaiah · Bengaluru, IN
• Olivia B. Faulkner · Shawnee, US
• Lisa Bielke · Wooster, US
• Billy Hargis · Fayetteville, US

Key dates

• Filing date: Jan 23, 2018
• Grant date: Jun 25, 2019
• Expiry date: Jan 23, 2038

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02A50/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Vaccine vectors and methods of using the vaccine vectors to enhance the immune response to an Apicomplexan parasite and reduce the morbidity or mortality associated with subsequent infection are provided herein. The vaccine vectors include a polynucleotide encoding a Rhomboid polypeptide and optionally include an immune-stimulatory polypeptide suitably expressed on the surface of the vaccine vector.