Patent · US Active

Compositions and methods for reducing neointima formation

US10328182B2 · kind B2 · utility

2Cited by

70References

20Claims

0Family size

Assignee

University of Georgia Research Foundation, Inc. · US

Inventors

Shiyou Chen · Sydney, AU
Rui Tang · Athens, US

Key dates

Filing date	Nov 16, 2015
Grant date	Jun 25, 2019
Priority date	—
Expiry date	Aug 26, 2036

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12N2310/531
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

Compositions, devices, grafts and methods for reducing or preventing anti-neointima following cardiovascular injuries and interventions are disclosed. The compositions, devices, and grafts typically include an effective amount of a CTP synthase 1 inhibitor to reduce proliferation of vascular smooth muscle cells, without substantial reducing the proliferation of endothelial cells. Methods of reducing neointima formation, accelerating re-endothelialization, and reducing restenosis in a subject using the compositions, devices, and grafts are also disclosed.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.