System and method for novel chance-constrained optimization in intensity-modulated proton therapy planning to account for range and patient setup uncertainties
US10328282B2 · kind B2 · utility
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Key dates
| Filing date | Jul 13, 2016 |
| Grant date | Jun 25, 2019 |
| Priority date | — |
| Expiry date | Sep 26, 2036 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61N2005/1087
- WIPO fieldMedical technology
- WIPO sectorInstruments
Abstract
A system and methods are provided for generating intensity modulated proton therapy plans robust to various kinds of delivery uncertainties with the capability for treatment planners to control the balance between plan quality and robustness. The system obtains a representation of a subject and a proton beam configuration that describes a number of beamlets and their respective arrangement. The system computes an objective function, in the treatment planning system, first part of which is about dose deviations from the prescribed dose in the target volumes, second part of which is about dose deviations from the dose constraint in the non-target volumes, and computing dose volume constraints for targets using a probability to control the dose distribution in the target volumes to be between a lower threshold and an upper threshold. Based on this information, the system obtains a robust chance-constrained treatment planning model with a user-adjustable tolerance level.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.