Patent · US Active

Process for the preparation of 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide and intermediates thereof

US10329254B2 · kind B2 · utility

0Cited by

5References

18Claims

0Family size

Assignee

AOP Orphan Pharmaceuticals AG · AT

Inventors

Enrica Diodato · Siena, IT
Katia Marcucci · Siena, IT
Russell Thomas · Verona, IT
Paul Wiedenau · Deal, GB
Martin Rettig · Schwanau, DE
Huw Roberts · Borth, GB

Key dates

Filing date	Apr 20, 2016
Grant date	Jun 25, 2019
Priority date	—
Expiry date	Apr 20, 2036

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07D209/88
WIPO fieldOrganic fine chemistry
WIPO sectorChemistry

Abstract

The invention relates to a novel process for the preparation of rac-6-Chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide (I) in pharmaceutically acceptable polymorphic form, through the conversion of a 3-bromo-2-oxo-cyclohexanecarboxylic acid alkyl ester into 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxylic acid alkyl ester, which in turn is processed to yield the final product.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.