Salts of an LSD1 inhibitor

US10329255B2 · kind B2 · utility

Assignee

• Incyte Corporation · US

Inventors

• Yongchun Pan · Wilmington, US
• Wayne Han · West Chester, US
• Ganfeng Cao · Bear, US
• Zhongjiang Jia · Kennett Square, US
• Vaqar Sharief · Nonatum Mills, US
• Jiacheng Zhou · Shanghai, CN

Key dates

• Filing date: Aug 11, 2016
• Grant date: Jun 25, 2019
• Expiry date: Aug 11, 2036

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D211/32
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present disclosure relates to tosylate salts 1-{[4-(methoxymethyl)-4-({[(1R,2S)-2-phenylcyclopropyl]amino}methyl)piperidin-1-yl]methyl}cyclobutanecarboxylic acid, methods of preparation thereof, and intermediates in the preparation thereof, which are useful in the treatment of the LSD1-associated or mediated diseases such as cancer.