G protein-coupled receptor kinase inhibitors and methods for use of the same

US10329283B2 · kind B2 · utility

Assignee

• THE REGENTS OF THE UNIVERSITY OF MICHIGAN · US

Inventors

• Scott D. Larsen · Kalamazoo, US
• John J. Tesmer · Ann Arbor, US
• Helen Waldschmidt · Ann Arbor, US
• Kristoff Homan · Newton, US
• Michael William Wilson · Foster City, US

Key dates

• Filing date: Jun 27, 2016
• Grant date: Jun 25, 2019
• Expiry date: Jun 27, 2036

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D405/12
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Disclosed herein are novel GRK inhibitors and methods for their use in treating or preventing heart disease, such as cardiac failure, cardiac hypertrophy, and hypertension. In particular, disclosed herein are compounds of Formula (I) and pharmaceutically acceptable salt thereof, wherein the substituents are as described.