Bicyclic-fused heteroaryl or aryl compounds

US10329302B2 · kind B2 · utility

Assignee

• PFIZER INC. · US

Inventors

• John David Trzupek · Medford, US
• Katherine Lin Lee · Newton, US
• Mark Edward Bunnage · Sandwich, GB
• Seungil Han · Mystic, US
• David Hepworth · Concord, US
• Frank Eldridge Lovering · Acton, US
• John Paul Mathias · Sandwich, GB
• Nikolaos Papaioannou · Newton, US
• Betsy Susan Pierce · Kalamazoo, US
• Joseph Walter Strohbach · Mendon, US
• Stephen Wayne Wright · Old Lyme, US
• Christoph Wolfgang Zapf · San Francisco, US
• Lori Krim Gavrin · Philadelphia, US
• Arthur Lee · San Jose, US
• David R. Anderson · Salem, US
• Kevin Joseph Curran · Nyack, US
• Christoph Martin Dehnhardt · New York, US
• Eddine Saiah · Brookline, US
• Joel A. Goldberg · New Orleans, US
• Xiaolun Wang · San Diego, US
• Horng-Chih Huang · Chesterfield, US
• Richard Vargas · Bedford, US
• Michael Dennis Lowe · White Plains, US
• Akshay Patny · Waltham, US

Key dates

• Filing date: Jan 5, 2018
• Grant date: Jun 25, 2019
• Expiry date: Jan 5, 2038

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07F7/1804
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compounds, tautomers and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula Ia, as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.