Phenylpropanoid compound and preparation method and use thereof

US10329316B2 · kind B2 · utility

Assignee

• QIANJIN PHARMACEUTICAL CO., LTD. · CN

Inventors

• Peng Zhang · Nanhu, CN
• Kaifeng Peng · Hunan, CN
• Yun Gong · Cupertino, US
• Fujun Li · Nanhu, CN
• Nifu Liu · Hunan, CN
• Bohou Xia · Hunan, CN
• Limei Lin · Lo Wu, CN

Key dates

• Filing date: Sep 17, 2018
• Grant date: Jun 25, 2019
• Expiry date: Sep 17, 2038

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K2300/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention provides a phenylpropanoid compound and a preparation method and use thereof. The phenylpropanoid compound has a structural formula shown as formula (I), and the pharmaceutically acceptable salt has a structural formula shown as formula (II), formula (III), formula (IV), or formula (V). The phenylpropanoid compound and the pharmaceutically acceptable salt thereof have an effect on inhibiting a content of an inflammatory cytokine NO and an expression of an inflammatory cytokine TNF-α, have an effect on inhibiting a hydroxyl radical (—OH), thereby have anti-inflammatory and antioxidant activities, and has a good application prospect in preparing of a medicine for treating an inflammatory disease related to the above factors, such as cervicitis, endometritis, pelvic inflammatory disease, mastitis, sphagitis and/or arthritis.