Method for the synthesis of phosphorus atom modified nucleic acids
US10329318B2 · kind B2 · utility
18Cited by
441References
17Claims
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Key dates
| Filing date | May 30, 2017 |
| Grant date | Jun 25, 2019 |
| Priority date | — |
| Expiry date | May 30, 2037 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07H1/00
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Described herein are methods of syntheses of phosphorous atom-modified nucleic acids comprising chiral X-phosphonate moieties. The methods described herein provide backbone-modified nucleic acids in high diasteteomeric purity via an asymmetric reaction of an achiral molecule comprising a chemically stable H-phophonate moiety with a nucleoside/nucleotide.
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