Specific detection tool for mesenchymal and epithelial-mesenchymal transformed circulating tumor cells
US10329353B2 · kind B2 · utility
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16Claims
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Key dates
| Filing date | Mar 5, 2014 |
| Grant date | Jun 25, 2019 |
| Priority date | — |
| Expiry date | May 3, 2034 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2317/76
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention includes the discovery of cell-surface vimentin as a novel biomarker to detect and isolate mesenchymal and epithelial-mesenchymal transformed circulating tumor cells from blood of cancer patients. In addition, an antibody specific for the detection of cell-surface vimentin on circulating tumor cells and the use the antibody to detect, enumerate, and isolate CTC are provided.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.