Tamper resistant and dose-dumping resistant pharmaceutical dosage form

US10335373B2 · kind B2 · utility

Assignee

• GRUNENTHAL GMBH · DE

Inventors

• KLAUS WENING
• Lutz Barnscheid · Mönchengladbach, DE
• Sebastian Schwier · Aachen, DE

Key dates

• Filing date: Apr 17, 2013
• Grant date: Jul 2, 2019
• Expiry date: Apr 17, 2033

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P25/36
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A tamper-resistant pharmaceutical dosage form comprising a pharmacologically active ingredient embedded in a prolonged release matrix, which comprises a prolonged release matrix material selected from the group consisting of nonionic acrylic polymers and waxy materials and which provides prolonged release of the pharmacologically active ingredient, resistance against solvent extraction, resistance against grinding, and resistance against dose-dumping in aqueous ethanol.