Spiro[cyclobutane-1,3′-indolin]-2′-one derivatives as bromodomain inhibitors

US10336697B2 · kind B2 · utility

Assignee

• ORION CORPORATION · FI

Inventors

• Ravi Ujjinamatada · Anekal, IN
• Susanta Samajdar · Savanuru, IN
• Chandrasekhar Abbineni · Hyderabad, IN
• Subhendu Mukherjee
• Tero LINNANEN · Tuusula, FI
• Gerd Wohlfahrt · Helsinki, FI

Key dates

• Filing date: Jun 15, 2016
• Grant date: Jul 2, 2019
• Expiry date: Jun 15, 2036

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D453/02
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention provides novel spiro[cyclobutane-1,3′-indolin]-2′-one derivatives of formula (I)in which Cy, R1, R2, R4, L, and m have the meaning given in the specification, and pharmaceutically acceptable salts thereof. The compounds of formula (I) are useful as bromodomain inhibitors in the treatment or prevention of diseases or disorders where bromodomain inhibition is desired.