Compound for enhancing the coupling degree of complex TRPV4-KCa2.3 and anti-hypertension applications thereof
US10336712B2 · kind B2 · utility
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Key dates
| Filing date | May 12, 2017 |
| Grant date | Jul 2, 2019 |
| Priority date | — |
| Expiry date | May 12, 2037 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P9/12
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The applicant provides a compound for enhancing the space coupling degree of an endothelial cell ion channel complex TRPV4-KCa2.3 and anti-hypertension applications thereof. By finding the structural domains of the interacting sites of the endothelial cell ion channel complex TRPV4-KCa2.3, a compound with specificity which can act at the two interacting sites is prepared in the present invention. It is found that the compound can enhance the space coupling degree of the TRPV4-KCa2.3 complex and has great significance for the research and development of anti-hypertension drugs.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.