Inhibitors of beta-secretase

US10336717B2 · kind B2 · utility

Assignee

• Vitae Pharmaceuticals, LLC · US

Inventors

• Salvacion Cacatian · Conshohocken, US
• David A. Claremon · Audubon, US
• Lawrence Wayne Dillard · Yardley, US
• Klaus Fuchs · Ingelheim am Rhein, DE
• Niklas Heine · Eberhardzell, DE
• Lanqi Jia · Horsham, US
• Katerina Leftheris · Skillman, US
• Brian McKeever · Lake Ronkonkoma, US
• Angel Morales-Ramos · Blue Bell, US
• Suresh B. Singh · Kendall Park, US
• Shankar Venkatraman · Lansdale, US
• Guosheng Wu · Beijing, CN
• Zhongren Wu · Zhuhai, CN
• Zhenrong Xu · Forest Park, US
• Jing Yuan · Lansdale, US
• Yajun Zheng · Hockessin, US

Key dates

• Filing date: Oct 15, 2015
• Grant date: Jul 2, 2019
• Expiry date: Dec 6, 2035

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D513/10
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention is directed to a compound represented by the following structural formula or a pharmaceutically acceptable salt thereof. Pharmaceutical compositions and method of use of the compounds are also described.