Methods for synthesizing nucleotide analogues with disulfide linkers
US10336785B2 · kind B2 · utility
17Cited by
11References
4Claims
0Family size
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Key dates
| Filing date | Nov 4, 2016 |
| Grant date | Jul 2, 2019 |
| Priority date | — |
| Expiry date | Jul 5, 2037 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02P20/55
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present invention provides methods, compositions, mixtures and kits utilizing deoxynucleoside triphosphates comprising a 3′-O position capped by a group comprising methylenedisulfide as a cleavable protecting group and a detectable label reversibly connected to the nucleobase of said deoxynucleoside. Such compounds provide new possibilities for future sequencing technologies, including but not limited to Sequencing by Synthesis.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.