Patent · US Active

Peptides capable of reactivating p53 mutants

US10336789B2 · kind B2 · utility

1Cited by

1References

20Claims

0Family size

Assignee

YEDA RESEARCH AND DEVELOPMENT CO. LTD. · IL

Inventors

Moshe Oren · Wilmington, US
Varda Rotter · Rishon LeZion, IL
Perry Tal · Rehovot, IL

Key dates

Filing date	Oct 29, 2017
Grant date	Jul 2, 2019
Priority date	—
Expiry date	Oct 29, 2037

Classification

Technology area (CPC A)Human Necessities
CPC primaryA61K38/00
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The invention provides peptides that can reactivate p53 mutants efficiently and specifically, as well as methods that allow the identification, selection and isolation of such peptides, in a precise, cost and time effective manner. In particular, there are provided mutant p53 reactivating peptides that can restore the native wild type p53 folding, and hence the tumor suppressor activity, to the mutant p53 protein. Such peptides are useful for treating various conditions and diseases in which p53 is mutated.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.